Delhi: 5 Covid patients at Ganga Ram hospital suffer rectal bleeding due to CMV infection, one dies

Five Covid-19 patients at a number one personal facility right here have suffered from cytomegalovirus-related rectal bleeding through the second wave of the pandemic, the hospital authorities mentioned on Tuesday and claimed that it was being reported for the “first time” in immunocompetent individuals.

These patients reported at the ability 20-30 days after the prognosis of Covid, medical doctors at the Sir Ganga Ram Hospital mentioned.

Until now, it affected solely the immunocompromised patients, post-transplant, most cancers, AIDS and so on. however that is the “first time in India” that instances of CMV-related rectal bleeding in Covid-19 immunocompetent patients have been reported, a spokesperson of the hospital mentioned.

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According to Professor Anil Arora, chairman, Institute of Liver Gastroenterology and Pancreaticobiliary Sciences at the hospital, “During the second wave of the pandemic, in April-May, we have seen five cases of the CMV infection in otherwise immunocompetent patients with Covid-19.”

These patients introduced with ache within the stomach and bleeding throughout stool discharge. None of them had different predisposing immunosuppressed states accounting for this viral an infection, he mentioned.

The Covid an infection itself and the medicines used for its therapy (like steroids) do suppress the immunity of patients and make them vulnerable to unusual infections with diversified displays, the hospital mentioned in an announcement.

“One such opportunistic infection is from CMV Cytomegaloirus and it exists in 80 to 90 per cent of the Indian population in asymptomatic form as our immunity is strong enough to make it clinically asymptomatic. Clinical presentation with symptoms secondary to CMV is usually seen in patients whose immunity is compromised,” it mentioned.

But in these 5 instances, all patients introduced with a “low lymphocyte count (6-10 per cent as against a normal of 20-40 per cent)”, indicating Covid-induced suppression of immunity predisposing them to symptomatic reactivation of the CMV an infection, medical doctors mentioned.

These patients within the age group of 30-70 are from Delhi-NCR and 4 of them had introduced with a decrease gastrointestinal bleed, which is bleeding in stools, and one of them introduced with intestinal obstruction, the assertion mentioned.

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“Two of them had massive bleeding, one requiring emergency life-saving surgery in the form of the removal of the right side of the colon, while one of them succumbed due to massive bleeding and severe Covid-19 chest disease,” the hospital mentioned.

The three different patients had been efficiently handled with antiviral remedy with ganciclovir, Arora mentioned.

“Cytomegalovirus colitis was confirmed by PCR testing for CMV viremia and tissue biopsy from the large intestine, which showed intranuclear inclusion bodies which was further confirmed to be due to the CMV infection by the specific immunohistochemistry stains,” mentioned Dr Sunila Jain, a senior advisor pathologist at the hospital.

In such instances, a excessive index of suspicion and well timed intervention within the type of an early prognosis and efficient antiviral remedy can save many a treasured lives, opined Dr Praveen Sharma, senior advisor at the hospital”s gastroenterology division.

Meanwhile, the Moolchand hospital mentioned in an announcement that new instances and the flaring up of outdated anal fissure and piles in lots of Covid-19 patients or these within the restoration part have been reported in the previous couple of months.

A post-Covid affected person, a 55-year-old man, had come as an OPD affected person to the surgical division of the hospital with a four-day historical past of bleeding within the rectum, together with painful defecation for the final 12 days, the hospital authorities mentioned.

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The affected person mentioned he had been consuming four-five glasses of “kadah” a day for the final three months, medical doctors mentioned.

He was handled surgically and discharged in 24 hours. Subsequently, his signs had been discovered to have fully disappeared, the assertion mentioned.

According to Dr Sachin Ambekar, advisor, division of laparoscopic and minimal entry surgical procedure at the hospital, “Since March, I have regularly been seeing three to five OPD patients a day coming with symptoms of anal fissures and piles. On probing, patients have been found to be following home remedy treatments sent on WhatsApp groups.”

They have apparently been overdosing themselves with vitamin D, vitamin C as additionally natural and “kadah” preparations and which have, in the long run, flared up the signs of an current fissure or piles. Moreover, even new instances of acute anal fissures have been noticed, he mentioned.

Ambekar mentioned “overzealous use of ”kadah”, a herbal home-made concoction, is a leading cause of piles and anal fissures in Covid-19 and post-Covid-19 patients”.

These scorching concoctions over a time period dry up the mucous lining or membrane of the abdomen and intestines, inflicting extreme constipation and thus, main to anal fissures. Earlier, anal fissures with piles had been termed as life-style illnesses. In the current situation, it’s a “self-styled disease” brought about due to the stress and worry of contracting Covid-19, the physician mentioned.

Ambekar has “surgically treated roughly 350 patients of anal fissure and piles related to post Covid-19 home remedy therapies” since March, the hospital claimed, including that a lot of them required surgical intervention like laser remedy, MIPH, whereas some had been managed conservatively.

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